Activated vitamin D increases the amount of calcium the intestines can absorb from ingested food into the bloodstream and prevents the loss of calcium in the kidneys. It also modifies the activity of bone cells, playing a key role in the formation of new bone in both children and adults.
Therefore, its deficiency is linked to:
- Osteomalacia (adults): Higher doses of vitamin D can help prevent osteoporosis, falls, and fractures in older adults.
- Rickets (children): Vitamin D deficiency in children is characterized by delayed growth and soft, weak, and deformed long bones that bend and arch under their weight when they start walking.
Additionally, vitamin D deficiency has been associated with various health benefits, indicating a wide range of potential functions. However, studies reporting on vitamin D benefits still need cautious interpretation, as the benefits are not fully proven.
For instance, it plays a significant role in the prevention of different diseases such as:
- Infection Prevention: Some studies link vitamin D deficiency to more severe respiratory infections, including COVID-19, due to its role in immune system function.
- Cancer Prevention: Vitamin D may help prevent cancer. A study noted that 1,100 IU per day, along with calcium, significantly reduced the risk of cancer in a considerable percentage of patients.
- Metabolic Diseases: It plays an indirect but important role in carbohydrate and lipid metabolism, as reflected in its association with type 2 diabetes, metabolic syndrome, insulin secretion, insulin resistance, polycystic ovary syndrome, and obesity.
- Cardiovascular Risk: This includes dysfunction of endothelial cells, accelerating atherosclerosis, hypertension, or abnormal coagulation, ultimately leading to a higher risk of cardiovascular events.
- Dementia: Vitamin D deficiency increases the risk of developing dementia.
- Chronic Pain: Various studies suggest a relationship between vitamin D deficiency and chronic pain.
Certainly, vitamin D likely plays a role in many more biological processes that are still unknown. To date, scientific and epidemiological studies are needed to consolidate information from initial studies and establish all the postulated benefits of vitamin D.