Vitamin B12 behaves differently from almost every other vitamin we consume. While many nutrients pass through the intestinal wall with relative ease, B12 requires a precise and surprisingly fragile sequence of events. Its absorption is not passive. It is curated.
From a biological perspective, this makes sense. B12 is essential to nerve integrity, red blood cell formation, and cellular energy. The body treats it as a valuable substance — one that must be carefully handled, protected, and delivered to the right place.
The process begins in the mouth and ends in the distal ileum. In whole foods, B12 is bound tightly to protein. To release it, the body relies on adequate levels of gastric acid and the enzyme pepsin. This is where problems often begin. As women move through their forties, stomach acid production naturally tends to decline. Even a diet rich in meat with B12 may fail to deliver usable amounts if this first step is compromised.
Once released, B12 binds to haptocorrin, a protein found in saliva. This temporary partner shields the vitamin from the harsh acidic environment of the stomach. Later, in the duodenum, pancreatic enzymes remove this protective layer, allowing B12 to attach to its true carrier: intrinsic factor.
Intrinsic factor is produced by specialized cells in the stomach lining. Without it, B12 cannot be absorbed — no matter how much is consumed. This B12–intrinsic factor complex travels to the final section of the small intestine, where specific receptors recognize it and allow the vitamin
to enter the bloodstream.